This new study suggests that children have a stronger antibody response to covid-19 According to an article that appeared in the JAMA Network Open, children under the age of 10 naturally produce more antibodies to covid-19.
Kids 10 years and youthful produce extra antibodies in response to coronavirus an infection than adolescents and adults, research confirmed Monday..
The authors of the article, which appeared on JAMA Community Open, stated the discovering helped make clear why kids are much less vulnerable to extreme Covid-19 than adults, though it’s nonetheless a really lively space of analysis and it’s believed that there are numerous components at play.
More antibodies mean more protection
A team led by researchers at Weill Cornell Medicine examined nearly 32,000 New York City antibody tests between April and August 2020 and found that a similar number of the 1,200 children and 30,000 adults showed signs of past infection – 17 percent and 19 percent.
The scientists then examined a subset of patients who tested positive (85 children and 3,648 adults) for immunoglobulin G (IgG) antibody levels.
It is a key sort of “neutralizing” antibody that binds to the spike protein of the virus, stopping it from invading cells.
The 32 children aged 1 to 10 years showed mean IgG levels almost five times higher than 127 young adults aged 19 to 24 years.
Lastly, they centered on a subset of 126 optimistic sufferers aged one to 24 years, none of whom had skilled extreme Covid-19, to additional characterize the antibody response.
In the latter group, children aged 1 to 10 had on average more than twice the IgG antibody levels of adolescents aged 11 to 18, who in turn had more than double the average level of young adults aged 19 to 24 years.
The authors wrote: “Our findings suggest that the differences in the clinical manifestations of Covid-19 in pediatric patients compared to adult patients could be due in part to age-related immune responses.”
The fact that children are less prone to severe Covid-19 is somewhat counterintuitive, given how much they are affected by other respiratory diseases, and many theories abound.
Children Have Better Immunity Levels Than Adults, Study Suggests
An article published in Nature Communications last month by researchers in Australia suggested that children have more active “innate” immunity: the immune system’s first line of defense that kicks in before it generates antibodies, and involves cells such as neutrophils that they patrol the body for infections.
Another theory is related to the fact that children have fewer cellular receptors in their airways called “ACE2” that the coronavirus uses to enter our cells.
A paradoxical result of the new research was that antibody levels were lower for young adults, but increased again with age, even though we know older people are more vulnerable.
The authors admitted that they could not fully explain this and suggested that the reason for the higher hospitalization and death rates among the elderly could be related to higher rates of comorbidities.
Obesity, which is a major risk factor for severe Covid-19, is associated with a phenomenon called a “cytokine storm” in which the immune system kicks in and damages organs.
The truth that overweight folks have the next baseline degree of signaling proteins referred to as cytokines may be related to greater antibody manufacturing, the authors wrote.